Hydrochloric Acid → 2-[(E)-[6-(furan-2-yl)-3-methyl-6,7-dihydro-5H-1-benzofuran-4-ylidene]amino]guanidine;hydrochloride

HRID 1700567ノート

反応式

HRID 1700567 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:15][C:14](=O)[C:9]2[C:10]([CH3:13])=[CH:11][O:12][C:8]=2[CH2:7]1.[C:17]([NH:20][NH2:21])([NH2:19])=[NH:18].[ClH:22].Cl>C(O)C>[ClH:22].[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:15]/[C:14](=[N:21]\[NH:20][C:17]([NH2:19])=[NH:18])/[C:9]2[C:10]([CH3:13])=[CH:11][O:12][C:8]=2[CH2:7]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 183174076-(2-Furyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-oneHCID 178418668HCID 178418668、化合物

生成物 1

HCID 1784311432-[(E)-[6-(furan-2-yl)-3-methyl-6,7-dihydro-5H-1-benzofuran-4-ylidene]amino]guanidine;hydrochloride収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

To a mixture of 6-(2-furyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.22 g) and aminoguanidine hydrochloride (113 mg) were ethanol (20 ml) and 6N hydrochloric acid (0.088 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-6-(2-furyl)-4-guanidinoimino-3-methyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 47) (0.22 g).

後処理

  1. temperaturecooled
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washthe residue was washed with ethanol, ethyl acetate and isopropylether
  4. customdried

出典と根拠

ORDレコード
ord-9f57786235264c1ba6fd721005069136
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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