Hydrochloric Acid → HCID 178423650、化合物

HRID 1700569ノート

反応式

HRID 1700569 の反応式
[CH3:1][C:2]1[S:6][C:5]([CH:7]2[CH2:16][C:15](=O)[C:10]3[C:11](C)=[CH:12][O:13][C:9]=3[CH2:8]2)=[CH:4][CH:3]=1.[C:18]([NH:21][NH2:22])([NH2:20])=[NH:19].[ClH:23].Cl.[CH2:25](O)C>>[ClH:23].[NH:21](/[N:22]=[C:15]1\[CH:16]([CH3:25])[CH:7]([C:5]2[S:6][C:2]([CH3:1])=[CH:3][CH:4]=2)[CH2:8][C:9]2[O:13][CH:12]=[CH:11][C:10]\1=2)[C:18]([NH2:20])=[NH:19]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 183175876-(5-Methyl-2-thienyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-oneHCID 178418668HCID 178418668、化合物

生成物 1

HCID 178423650HCID 178423650、化合物

反応条件

温度
90 °C

実験手順

To a mixture of 6-(5-methyl-2-thienyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.18 g) and aminoguanidine hydrochloride (81 mg) were added ethanol (15 ml) and 6N hydrochloric acid (0.063 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-4-guanidinoimino-6-(5-methyl-2-thienyl)-5-methyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 49) (0.18 g).

後処理

  1. temperaturecooled
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washthe residue was washed with ethanol, ethyl acetate and isopropylether
  4. customdried

出典と根拠

ORDレコード
ord-b727f9491dd44d479cc28fa73c74fc5a
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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