Hydrochloric Acid → HCID 178434187、化合物

HRID 1700671ノート

反応式

HRID 1700671 の反応式
[Cl:1][C:2]1[S:3][C:4]([Cl:18])=[CH:5][C:6]=1[CH:7]1[CH2:15][C:14]2[NH:13][N:12]=[C:11]([CH3:16])[C:10]=2[C:9](=O)[CH2:8]1.Cl.[NH2:20][NH:21][C:22]([NH:24][OH:25])=[NH:23].Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[S:3][C:4]([Cl:18])=[CH:5][C:6]=1[CH:7]1[CH2:15][C:14]2[NH:13][N:12]=[C:11]([CH3:16])[C:10]=2[C:9](=[N:20][NH:21][C:22](=[NH:23])[NH:24][OH:25])[CH2:8]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 178434193HCID 178434193、化合物HCID 178479533HCID 178479533、化合物

生成物 1

HCID 178434187HCID 178434187、化合物収率 156.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

To a mixture of 6-(2,5-dichlorothiophen-3-yl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.211 g) and 1-amino-3-hydroxyguanidine hydrochloride (102 mg) were added ethanol (4 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was stirred at 90° C. for 4 hours. Under reduced pressure, the solvent was evaporated, and to the residue was ethanol (2 ml). Precipitated crystals were filtered, washed with ethanol and dried to give 6-(2,5-dichlorothiophen-3-yl)-4-(1-hydroxyguanidin-3-yl)imino-3-methyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 128) (0.225 g) as pale yellow crystals.

後処理

  1. customUnder reduced pressure, the solvent was evaporated
  2. customPrecipitated crystals
  3. filtrationwere filtered
  4. washwashed with ethanol
  5. customdried

出典と根拠

ORDレコード
ord-e3e2d3144d6a4be79ca470a1404fe6e8
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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