Hydrochloric Acid → HCID 178430926、化合物

HRID 1700674ノート

反応式

HRID 1700674 の反応式
[Cl:1][C:2]1[S:3][C:4]([Cl:19])=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N:14]=[N:13][CH:12]=[C:11]([CH3:17])[C:10]=2[C:9](=O)[CH2:8]1.[C:20]([NH:23][NH2:24])([NH2:22])=[NH:21].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[S:3][C:4]([Cl:19])=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N:14]=[N:13][CH:12]=[C:11]([CH3:17])[C:10]=2[C:9](=[N:24][NH:23][C:20]([NH2:22])=[NH:21])[CH2:8]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 183174407-(2,5-Dichlorothiophen-3-yl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-oneHCID 178418668HCID 178418668、化合物

生成物 1

HCID 178430926HCID 178430926、化合物収率 190.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a mixture of 7-(2,5-dichlorothiophen-3-yl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (0.203 g) and aminoguanidine hydrochloride (80 mg) were added ethanol (6 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 1.5 hours and cooled. Precipitated crystals were filtered, washed with ethanol and dried to give 7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 131) (0.25 g) as crystals.

後処理

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. temperaturecooled
  3. customPrecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol
  6. customdried

出典と根拠

ORDレコード
ord-3bf440d775a045339eaa2adb1ab56f47
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

読み込み中…