Ammonium Acetate → 1-Amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one

HRID 1700696ノート

反応式

HRID 1700696 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][C:13](=O)[CH2:12][C:11](=[O:16])[CH2:10]1.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][C:13]1[CH2:14][CH:9]([C:3]2[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=2[F:1])[CH2:10][C:11](=[O:16])[CH:12]=1

参加物

4

反応物 2

HCID 517165Ammonium AcetateHCID 183174315-(2-Fluoro-5-methylphenyl)cyclohexane-1,3-dione

生成物 1

HCID 183176231-Amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one収率 87.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 5-(2-fluoro-5-methylphenyl)cyclohexane-1,3-dione (1.5 g) and ammonium acetate (1.6 g) in ethanol (23 ml) was refluxed for 20 hours. Under reduced pressure, the solvent was evaporated, and precipitated crystals were washed with water and toluene, and dried to give 1-amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one (1.3 g).

後処理

  1. customUnder reduced pressure, the solvent was evaporated
  2. customprecipitated crystals
  3. washwere washed with water and toluene
  4. customdried

出典と根拠

ORDレコード
ord-15bf297343ad43148504d34913f2ae9b
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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