Hydrochloric Acid → 6-(2-Chlorophenyl)-4-guanidinoimino-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazole hydrochloride

HRID 1700737ノート

反応式

HRID 1700737 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:16][C:15]2[C:11](=[C:12]([CH3:23])[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=2)[C:10](=O)[CH2:9]1.[C:25]([NH:28][NH2:29])([NH2:27])=[NH:26].Cl.Cl.O>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:16][C:15]2[C:11](=[C:12]([CH3:23])[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=2)[C:10](=[N:29][NH:28][C:25]([NH2:27])=[NH:26])[CH2:9]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 183175566-(2-Chlorophenyl)-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazol-4-oneHCID 178418668HCID 178418668、化合物

生成物 1

HCID 1784216616-(2-Chlorophenyl)-4-guanidinoimino-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazole hydrochloride収率 190.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 6-(2-chlorophenyl)-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazol-4-one (0.6 g), aminoguanidine hydrochloride (0.24 g), concentrated hydrochloric acid (0.45 ml), water (0.45 ml) and ethanol (20 ml) was refluxed for 12 hours. Under reduced pressure, the solvent was evaporated, and the resulting crystals were recrystallized from ethanol-water to give 6-(2-chlorophenyl)-4-guanidinoimino-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 150) (0.73 g) as colorless crystals.

後処理

  1. temperaturewas refluxed for 12 hours
  2. customUnder reduced pressure, the solvent was evaporated
  3. customthe resulting crystals were recrystallized from ethanol-water

出典と根拠

ORDレコード
ord-50dde398f6c14ae9a54fe4281a8fce0f
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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