Hydrochloric Acid → HCID 178430929、化合物

HRID 1700743ノート

反応式

HRID 1700743 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N:15]=[N:14][CH:13]=[C:12]([CH3:18])[C:11]=2[C:10](=O)[CH2:9]1.Cl.[NH2:21][NH:22][C:23]([NH:25][OH:26])=[NH:24].Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N:15]=[N:14][CH:13]=[C:12]([CH3:18])[C:11]=2[C:10](=[N:21][NH:22][C:23](=[NH:24])[NH:25][OH:26])[CH2:9]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 110439264-Methyl-7-(2-chlorophenyl)-5,6,7,8-tetrahydrocinnolin-5-oneHCID 178479533HCID 178479533、化合物

生成物 1

HCID 178430929HCID 178430929、化合物収率 155.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (101 mg) and 1-amino-3-hydroxyguanidine hydrochloride (48 mg) were added ethanol (2 ml) and concentrated hydrochloric acid (0.05 ml), and the mixture was stirred at 90° C. for 1.5 hours. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol and dried to give 7-(2-chlorophenyl)-5-(1-hydroxyguanidin-3-yl)imino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 156) (110 mg) as gray white crystals.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe residue was washed with ethanol
  3. customdried

出典と根拠

ORDレコード
ord-74945a8e986c4309b9c1fccf668ebf59
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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