Hydrochloric Acid → HCID 178428728、化合物

HRID 1700744ノート

反応式

HRID 1700744 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N+:15]([O-:18])=[CH:14][CH:13]=[C:12]([CH3:19])[C:11]=2[C:10](=O)[CH2:9]1.[C:21]([NH:24][NH2:25])([NH2:23])=[NH:22].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N+:15]([O-:18])=[CH:14][CH:13]=[C:12]([CH3:19])[C:11]=2[C:10](=[N:25][NH:24][C:21]([NH2:23])=[NH:22])[CH2:9]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 183177547-(2-Chlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one-1-oxideHCID 178418668HCID 178418668、化合物

生成物 1

HCID 178428728HCID 178428728、化合物収率 144.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one-1-oxide (0.23 g) and aminoguanidine hydrochloride (100 mg) were added ethanol (6 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 3 hours. The reaction solution was cooled to room temperature, and the resulting crystals were filtered and dried to give 7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline-1-oxide hydrochloride (Compound 157) (220 mg) as colorless crystals.

後処理

  1. temperaturethe mixture was refluxed for 3 hours
  2. filtrationthe resulting crystals were filtered
  3. customdried

出典と根拠

ORDレコード
ord-3e9fd6e8b1c64ba5953350fc5106dee4
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

読み込み中…