Benzophenone imine → [(Diphenylmethylene)amino]acetonitrile

HRID 17008

反応式

HRID 17008 の反応式
[C:1](=[NH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:16][CH2:17][C:18]#N>ClCCl>[C:1](=[N:14][CH2:18][C:17]#[N:16])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 136809Benzophenone imineHCID 11491918Aminoacetonitrile hydrochloride

生成物 1

HCID 612957[(Diphenylmethylene)amino]acetonitrile収率 157.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of benzophenone imine (25 g, 0.138 mol, Aldrich) and aminoacetonitrile hydrochloride (25 g, 0.270 mol, Lancaster) in dichloromethane (1000 mL) was stirred in a 2 L Erlenmeyer flask under nitrogen at room temperature for 5 days. The reaction mixture was filtered to remove the precipitated ammonium chloride and the filtrate was evaporated to dryness in vacuo. The resulting residue was dissolved in ether (400 mL) washed with water (200 mL) and brine. After drying over magnesium sulfate the solution was evaporated to give (benzhydrylideneamino)acetonitrile (47.89 g).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customto remove the precipitated ammonium chloride
  3. customthe filtrate was evaporated to dryness in vacuo
  4. dissolutionThe resulting residue was dissolved in ether (400 mL)
  5. washwashed with water (200 mL) and brine
  6. dry with materialAfter drying over magnesium sulfate the solution
  7. customwas evaporated

出典と根拠

ORDレコード
ord-94fa87f1999c47d2b174ae1ff9bd6c42
出典データセット
uspto-grants-2010_06
特許番号
US07737300B2

関連ノート

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