1,2-Dibromoethane → 1-(2-Bromoethoxy)-4-iodobenzene

HRID 1700889ノート

反応式

HRID 1700889 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[Br:9][CH2:10][CH2:11]Br.C(=O)([O-])[O-].[K+].[K+]>>[Br:9][CH2:10][CH2:11][O:8][C:5]1[CH:6]=[CH:7][C:2]([I:1])=[CH:3][CH:4]=1

参加物

4

反応物 3

HCID 78391,2-DibromoethaneHCID 108944-IodophenolHCID 11430Potassium Carbonate

生成物 1

HCID 19058471-(2-Bromoethoxy)-4-iodobenzene収率 84%

実験手順

A mixture of 4-iodophenol (15.0 g, 68.2 mmol) and 1,2-dibromoethane (50 ml, 580 mmol) and potassium carbonate (14.0 g, 0.1 mol) was stirred and refluxed for 22 h. After cooling to r.t., the mixture was filtered, washed with ethyl acetate and concentrated in vacuo. The residue was chromatographed on silica gel (Hexane/ethyl acetate 40:1 to 20:1) to afford the title compound (18.7 g, 84%) as a white solid.

後処理

  1. temperaturerefluxed for 22 h
  2. filtrationthe mixture was filtered
  3. washwashed with ethyl acetate
  4. concentrationconcentrated in vacuo
  5. customThe residue was chromatographed on silica gel (Hexane/ethyl acetate 40:1 to 20:1)

出典と根拠

ORDレコード
ord-e13ce39eeaa34889902dcc3c10961964
出典データセット
uspto-grants-2002_02
特許番号
US06350892B1

反応ノート

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