Leurosine sulfate → methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate

HRID 1701091

反応式

HRID 1701091 の反応式
[CH3:1][CH2:2][C@@:3]12[O:22][C@@H:21]1[C@@H:19]1[CH2:20][N:5]([CH2:6][CH2:7][C:8]3[C:9]4[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=4[NH:15][C:16]=3[C@@:17]([C:56]([O:58][CH3:59])=[O:57])([C:23]3[CH:24]=[C:25]4[C@:33]56[C@@H:37]7[C@:38]([CH2:53][CH3:54])([C@@H:42]([O:49][C:50]([CH3:52])=[O:51])[C@:43]([OH:48])([C:44]([O:46][CH3:47])=[O:45])[C@@H:32]5[N:31]([CH3:55])[C:26]4=[CH:27][C:28]=3[O:29][CH3:30])[CH:39]=[CH:40][CH2:41][N:36]7[CH2:35][CH2:34]6)[CH2:18]1)[CH2:4]2.OS(O)(=O)=O>O>[CH3:1][CH2:2][C@@:3]12[O:22][C@@H:21]1[C@H:19]1[CH2:20][N:5]([CH2:6][CH2:7][C:8]3[C:9]4[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=4[NH:15][C:16]=3[C@@:17]([C:56]([O:58][CH3:59])=[O:57])([C:23]3[CH:24]=[C:25]4[C@:33]56[C@@H:37]7[C@:38]([CH2:53][CH3:54])([C@@H:42]([O:49][C:50]([CH3:52])=[O:51])[C@:43]([OH:48])([C:44]([O:46][CH3:47])=[O:45])[C@@H:32]5[N:31]([CH3:55])[C:26]4=[CH:27][C:28]=3[O:29][CH3:30])[CH:39]=[CH:40][CH2:41][N:36]7[CH2:35][CH2:34]6)[CH2:18]1)[CH2:4]2

参加物

3

反応物 1

HCID 259897Leurosine sulfate

生成物 1

HCID 442111methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

About 0.25 g. of leurosine sulfate were converted to the free base by dissolving the salt in water and making the resulting solution alkaline. The free base was insoluble in the aqueous alkaline layer and was extracted with chloroform. Evaporation of the chloroform yielded leurosine free base as a residue.

後処理

  1. extractionwas extracted with chloroform
  2. customEvaporation of the chloroform

出典と根拠

ORDレコード
ord-580e176d2e18422ea17dc317244860dc
出典データセット
uspto-grants-1980_03
特許番号
US04191688

関連ノート

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