Triethylamine → 11beta-Dipropylaminoacetoxy-3alpha-hydroxy-5alpha-pregnan-20-one

HRID 1701430ノート

反応式

HRID 1701430 の反応式
[CH2:1]([N:4]([CH2:8][C:9]([O:11][C@H:12]1[CH2:31][C@@:30]2([CH3:32])[C@@H:23]([CH2:24][CH2:25][C@@H:26]2[C:27](=[O:29])[CH3:28])[C@H:22]2[C@H:13]1[C@:14]1([CH3:34])[C@@H:19]([CH2:20][CH2:21]2)[CH2:18][C:17](=[O:33])[CH2:16][CH2:15]1)=[O:10])[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3].C(N(CC)CC)C>C(=O)(O)[O-].[Na+].O.Cl.Cl.Cl[Ir](Cl)(Cl)Cl>[CH2:1]([N:4]([CH2:8][C:9]([O:11][C@H:12]1[CH2:31][C@@:30]2([CH3:32])[C@@H:23]([CH2:24][CH2:25][C@@H:26]2[C:27](=[O:29])[CH3:28])[C@H:22]2[C@H:13]1[C@:14]1([CH3:34])[C@@H:19]([CH2:20][CH2:21]2)[CH2:18][C@H:17]([OH:33])[CH2:16][CH2:15]1)=[O:10])[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3]

参加物

5

反応物 2

HCID 8471TriethylamineHCID 7058369811beta-Dipropylaminoacetoxy-5alpha-pregnane-3,20-dione

生成物 1

HCID 2281032311beta-Dipropylaminoacetoxy-3alpha-hydroxy-5alpha-pregnan-20-one

試薬・触媒・溶媒 2

HCID 16211483Tetrachloroiridium--hydrogen chloride--water (1/2/1)触媒HCID 516892Sodium Bicarbonate溶媒

実験手順

11β-Dipropylaminoacetoxy-5α-pregnane-3,20-dione (300 mg) was added to a solution of chloroiridic acid reagent (10 ml) containing triethylamine (1.1 ml). The mixture was boiled for about 20 minutes, cooled and diluted with sodium bicarbonate solution and the precipitated solid collected by filtration to afford title compound, m.p. 107°-115°, [α]D +91.3° (230 mg).

後処理

  1. temperaturecooled
  2. filtrationthe precipitated solid collected by filtration

出典と根拠

ORDレコード
ord-b6694a3c81e8453abc5839ffbb513d5d
出典データセット
uspto-grants-1980_03
特許番号
US04192871

反応ノート

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