Carbon Dioxide → N-(2,6-Diethyl-phenyl)-N'-tert.-butyl-thiourea

HRID 1701561ノート

反応式

HRID 1701561 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[N:11]=[C:12]=[S:13])[CH3:2].C([C:16]1C=CC=[C:19](CC)[C:17]=1[NH2:18])C.[C:25](=O)([O-])[O-].[Ca+2].C(Cl)(Cl)=S.C(=O)=O>C(Cl)Cl.O>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([NH:18][C:17]([CH3:19])([CH3:25])[CH3:16])=[S:13])[CH3:2]

参加物

8

反応物 5

HCID 280Carbon DioxideHCID 10040ThiophosgeneHCID 10112Calcium CarbonateHCID 113692,6-DiethylanilineHCID 1411932,6-Diethylphenyl isothiocyanate

生成物 1

HCID 20346927N-(2,6-Diethyl-phenyl)-N'-tert.-butyl-thiourea

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

2,6-Diethyl-phenyl isothiocyanate can be prepared as follows: 100 g of 2,6-diethylaniline in 200 ml of methylene chloride are added dropwise at 0°-5°, whilst stirring, to a mixture of 500 ml of methylene chloride, 300 ml of water, 120 g of calcium carbonate and 92 g of thiophosgene. The mixture is then heated to the reflux temperature until the evolution of CO2 has ended. The cooled batch is filtered and the methylene chloride layer is separated off, dried with calcium chloride and fractionated.

後処理

  1. filtrationThe cooled batch is filtered
  2. customthe methylene chloride layer is separated off
  3. dry with materialdried with calcium chloride

出典と根拠

ORDレコード
ord-f9f97215daf94e67ae5df4197d44dfa3
出典データセット
uspto-grants-1980_03
特許番号
US04194008

反応ノート

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