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Hydrochloric Acid → N-(2,6-Diisopropyl-phenyl)-N'-(3-trifluoromethyl-cyclohexyl)thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Isothiocyanato-1,3-bis(propan-2-yl)benzene | HCID 141194 | — |
| 反応物 | 3-(Trifluoromethyl)cyclohexylamine (cis-and trans-mixture) | HCID 16227766 | — |
| 生成物 | N-(2,6-Diisopropyl-phenyl)-N'-(3-trifluoromethyl-cyclohexyl)thiourea | HCID 20347045 | — |
反応手順
16.0 g of 3-trifluoromethyl-cyclohexylamine are taken and 18.0 g of 2,6-diisopropyl-phenyl isothiocyanate are introduced whilst stirring. The reaction commences with slight evolution of heat. The mixture is left to stand for 12 hours and is then stirred with dilute hydrochloric acid. The crystalline product is filtered off, triturated with dilute methanol, filtered off and dried. The compound is obtained in the form of a stereomer mixture of melting point 67°-75° C.; yield 27 g. The elementary analysis and NMR and IR spectra agree with the assumed structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04194008 |
| 出典データセット | uspto-grants-1980_03 |
| ORD ID | ord-4ae2509c66324cd5a707c69dd2da05a1 |
| 出典メモ | uspto-grants-1980_03 |