Bromine → alpha-Bromo-3-chloropropiophenone

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH2:9][CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:12]Br>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH:9]([Br:12])[CH3:10])[CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 24408Bromine2 回

HCID 5871283'-Chloropropiophenone

生成物 1

HCID 4992116alpha-Bromo-3-chloropropiophenone

実験手順

To 1 mole of m-chloropropiophenone heated to 60±5° C., bromine was added dropwise under stirring. The reaction temperature was kept at 60±5° C. during the addition of bromine, and kept for 5.5 hours after the addition. m-Chloro-α-bromopropiophenone (compound of formula (II)) was obtained.

後処理

additionafter the addition

出典と根拠

ORDレコード: ord-82d524a4fede43a787b399d1de854e8d
出典データセット: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07737302B2

反応ノート

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