Dimethylamine → 3-Chloro-N,N-dimethylpyrazin-2-amine
反応式
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:9][NH:10][CH3:11]>>[Cl:8][C:7]1[C:2]([N:10]([CH3:11])[CH3:9])=[N:3][CH:4]=[CH:5][N:6]=1参加物
3
実験手順
74 g of 2,3-dichloro-pyrazine are added dropwise over the course of 15 minutes, whilst stirring, to 350 ml of a 40% strength aqueous solution of dimethylamine. Whilst doing so, the reaction temperature is kept at 30° C. by cooling. When the exothermic reaction has subsided the mixture is stirred for a further 15 hours at room temperature. The reaction mixture is then extracted by shaking with ether. The ether extracts are washed with water until neutral, dried over sodium sulphate and evaporated in a waterpump vacuum. The residue is distilled in a waterpump vacuum. 2-Chloro-3-dimethylamino-pyrazine, boiling point 100°-102° C./10 mm Hg, is thus obtained.
後処理
- customis kept at 30° C.
- temperatureby cooling
- customWhen the exothermic reaction
- extractionThe reaction mixture is then extracted
- stirringby shaking with ether
- washThe ether extracts are washed with water until neutral,
- dry with materialdried over sodium sulphate
- customevaporated in a waterpump vacuum
- distillationThe residue is distilled in a waterpump vacuum
出典と根拠
- ORDレコード
- ord-c660aa2b0ef545c1924734c324297d1d
- 出典データセット
- uspto-grants-1980_03
- 特許番号
- US04195090
反応ノート
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