Diethylamine → ethyl 5-(N,N-diethylaminomethyl)-2-furoate

HRID 1701800

反応式

HRID 1701800 の反応式
Cl[CH2:2][C:3]1[O:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=1.[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14]>C1C=CC=CC=1>[CH2:13]([N:15]([CH2:2][C:3]1[O:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=1)[CH2:16][CH3:17])[CH3:14]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 263166Ethyl 5-(chloromethyl)-2-furancarboxylate

生成物 1

HCID 20346154ethyl 5-(N,N-diethylaminomethyl)-2-furoate

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Ethyl 5-(chloromethyl)-2-furoate (0.1 mole) is refluxed with diethylamine (0.25 mole) in 40 ml of benzene for one hour. The benzene solution is filtered off and washed with water. The organic layer is separated and dried over magnesium sulfate. The magnesium sulfate is removed by filtration and the organics are evaporated to dryness. The residue is distilled to give a pure fraction of ethyl 5-(N,N-diethylaminomethyl)-2-furoate boiling at 97°-106° C. at 0.1 mm of Hg.

後処理

  1. filtrationThe benzene solution is filtered off
  2. washwashed with water
  3. customThe organic layer is separated
  4. dry with materialdried over magnesium sulfate
  5. customThe magnesium sulfate is removed by filtration
  6. customthe organics are evaporated to dryness
  7. distillationThe residue is distilled

出典と根拠

ORDレコード
ord-3dc60f99f2a140ba89ca3e4738118d19
出典データセット
uspto-grants-1980_03
特許番号
US04195023

関連ノート

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