Acetamide, N-(2,4-dimethyl-5-nitrophenyl)- → Acetamide, N-(5-amino-2,4-dimethylphenyl)-

HRID 1702117ノート

反応式

HRID 1702117 の反応式
[CH3:1][C:2]1[C:7]([NH:8][C:9]([CH3:11])=[O:10])=[CH:6][C:5]([N+:12]([O-])=O)=[C:4]([CH3:15])[CH:3]=1.[H][H].[S]>C(O)C.[Ni]>[CH3:15][C:4]1[C:5]([NH2:12])=[CH:6][C:7]([NH:8][C:9]([CH3:11])=[O:10])=[C:2]([CH3:1])[CH:3]=1

参加物

6

反応物 3

HCID 112848Acetamide, N-(2,4-dimethyl-5-nitrophenyl)-HCID 5362487SulfurHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 104605Acetamide, N-(5-amino-2,4-dimethylphenyl)-

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

2,4-Dimethyl-5-nitroacetanilide (20.8 g., 100 mmole) in ethanol (400 ml.) was reduced over Raney nickel at about 45 psi of hydrogen gas. After the hydrogen uptake was complete, the mixture was deactivated with elementary sulfur, filtered, and the filtrate was evaporated under reduced pressure to give the product as a solid, m.p. 163°-164° C.

後処理

  1. filtrationfiltered
  2. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-df332bd22928459b9d6d0a925c87e2e5
出典データセット
uspto-grants-1983_04
特許番号
US04380464

反応ノート

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