Bromine → 5-Bromo-2,3-bis(4-fluorophenyl)thiophene

HRID 1702469ノート

反応式

HRID 1702469 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[CH:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[Br:20]Br>C(Cl)Cl.C(O)(=O)C>[Br:20][C:10]1[S:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[C:12]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:11]=1

参加物

5

反応物 2

HCID 24408Bromine2 回HCID 119758142,3-Bis(4-fluorophenyl)thiophene

生成物 1

HCID 131272535-Bromo-2,3-bis(4-fluorophenyl)thiophene

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒3 回HCID 6344Dichloromethane溶媒

実験手順

A solution of 2,3-bis(4-fluorophenyl)thiophene (272 mg, 1 mmole) in 3 ml methylene chloride was diluted with 3 ml glacial acetic acid and cooled to 10°. A solution of 0.5 M bromine in acetic acid (1.1 ml) was added. After 21/2 hours an additional portion of bromine in acetic acid (1.1 ml) was added. After a total rection time of 51/2 hours, the reaction mixture was concentrated in vacuo.

後処理

  1. temperaturecooled to 10°
  2. concentrationAfter a total rection time of 51/2 hours, the reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-2611a991d4dc4ef6a78006123151b64d
出典データセット
uspto-grants-1983_04
特許番号
US04381311

反応ノート

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