Rmi 82249 → 1,3-diacetyl-1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one

HRID 1702485

反応式

HRID 1702485 の反応式
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([C:7]([C:9]2[NH:10][C:11](=[O:15])[NH:12][C:13]=2[CH3:14])=[O:8])=[CH:5][CH:4]=1>C(OC(=O)C)(=O)C>[C:3]([N:12]1[C:13]([CH3:14])=[C:9]([C:7](=[O:8])[C:6]2[CH:16]=[CH:17][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[N:10]([C:7](=[O:8])[CH3:6])[C:11]1=[O:15])(=[O:2])[CH3:4]

参加物

3

反応物 1

HCID 132464Rmi 82249

生成物 1

HCID 128560311,3-diacetyl-1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

A mixture of 46.4 g of 1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one and 200 ml of acetic anhydride is refluxed for 2 hours. The mixture is distilled to remove 100 ml of acetic anhydride and acetic acid; this is replaced by fresh acetic anhydride and refluxing is resumed. After a total of 4 hours of reflux, excess acetic anhydride is evaporated under reduced pressure and the resulting residue is crystallized from ethanol to give 1,3-diacetyl-1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one melting at about 123°-125° C.

後処理

  1. temperatureis refluxed for 2 hours
  2. distillationThe mixture is distilled
  3. customto remove 100 ml of acetic anhydride and acetic acid
  4. temperaturerefluxing
  5. temperatureAfter a total of 4 hours of reflux
  6. customexcess acetic anhydride is evaporated under reduced pressure
  7. customthe resulting residue is crystallized from ethanol

出典と根拠

ORDレコード
ord-189f531d9dd84ce7a7b09b2df661c72f
出典データセット
uspto-grants-1983_04
特許番号
US04381393

関連ノート

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