Dimethylamine → 4-[(dimethylamino)methyl]-1,3-dihydro-5-(4-methoxybenzoyl)-2H-imidazol-2-one

HRID 1702487ノート

反応式

HRID 1702487 の反応式
Br[CH2:2][C:3]1[NH:7][C:6](=[O:8])[NH:5][C:4]=1[C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1.[CH3:19][NH:20][CH3:21]>C(O)C>[CH3:19][N:20]([CH2:2][C:3]1[NH:7][C:6](=[O:8])[NH:5][C:4]=1[C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)[CH3:21]

参加物

4

反応物 2

HCID 674DimethylamineHCID 128560344-(bromomethyl)-1,3-dihydro-5-(4-methoxybenzoyl)-2H-imidazol-2-one

生成物 1

HCID 131183744-[(dimethylamino)methyl]-1,3-dihydro-5-(4-methoxybenzoyl)-2H-imidazol-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
25 °C

実験手順

A mixture of 3.1 g of 5-(bromomethyl)-1,3-dihydro-4-(4-methoxybenzoyl)-2H-imidazol-2-one, 12 ml of 30% aqueous dimethylamine and 24 ml of ethanol is stirred at 25° C. for 2 hours. The solvent is then evaporated from the mixture under reduced pressure and the resultant residue is recrystallized twice from ethanol to give 4-[(dimethylamino)methyl]-1,3-dihydro-5-(4-methoxybenzoyl)-2H-imidazol-2-one melting at about 165°-167° C. with decomposition.

後処理

  1. customThe solvent is then evaporated from the mixture under reduced pressure
  2. customthe resultant residue is recrystallized twice from ethanol

出典と根拠

ORDレコード
ord-c7ff0616b2e04d06beea01efd75289ad
出典データセット
uspto-grants-1983_04
特許番号
US04381393

反応ノート

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