Hydrochloric Acid → HCID 20504009、化合物

HRID 1702489

反応式

HRID 1702489 の反応式
Br[CH2:2][C:3]1[NH:4][C:5](=[O:18])[NH:6][C:7]=1[C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1.[ClH:19].Cl.[CH3:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1.C(=O)([O-])[O-].[K+].[K+].Cl>C(O)C.O>[ClH:19].[CH3:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([C:8]([C:7]2[NH:6][C:5](=[O:18])[NH:4][C:3]=2[CH2:2][N:31]2[CH2:32][CH2:33][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH3:21])[CH2:29][CH2:30]2)=[O:17])=[CH:10][CH:11]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 919641-(o-Tolyl)piperazine dihydrochlorideHCID 128560344-(bromomethyl)-1,3-dihydro-5-(4-methoxybenzoyl)-2H-imidazol-2-one

生成物 1

HCID 20504009HCID 20504009、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of 6.2 g of 4-(bromomethyl)-1,3-dihydro-5-(4-methoxybenzoyl)-2H-imidazol-2-one, 5.0 g of 1-(2-methylphenyl)piperazine dihydrochloride and 5.4 g of potassium carbonate in 100 ml of ethanol is stirred at room temperature for 24 hours. Water is added to the reaction mixture and the precipitate which forms is separated by filtration. The solid is then suspended in 2-propanol, 1 equivalent of hydrochloric acid is added, and the resulting solid is separated and recrystallized from 2-propanol/water to give 1,3-dihydro-4-(4-methoxybenzoyl)-5-[[4-(2-methylphenyl)-1-piperazinyl]methyl]-2H-imidazol-2-one hydrochloride melting at about 223°-225° C. with decomposition.

後処理

  1. customthe precipitate which forms is separated by filtration
  2. customthe resulting solid is separated
  3. customrecrystallized from 2-propanol/water

出典と根拠

ORDレコード
ord-cef395f726b446778236056e147d2127
出典データセット
uspto-grants-1983_04
特許番号
US04381393

関連ノート

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