Timonacic → 3-[4-(Hexadecylamino)cinnamoyl]-4-carboxythiazolidine

HRID 1702702ノート

反応式

HRID 1702702 の反応式
[CH2:1]([NH:17][C:18]1[CH:37]=[CH:36][C:21]([CH:22]=[CH:23][C:24]([N:26]2[CH:30]([C:31]([O:33]CC)=[O:32])[CH2:29][S:28][CH2:27]2)=[O:25])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([CH:22]=[CH:23][C:24]([N:26]2[CH:30]([C:31]([OH:33])=[O:32])[CH2:29][S:28][CH2:27]2)=[O:25])=[CH:36][CH:37]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

4

反応物 2

HCID 9934TimonacicHCID 544239453-[4-(Hexadecylamino)cinnamoyl]-4-carboethoxy thiazolidine

生成物 1

HCID 538485433-[4-(Hexadecylamino)cinnamoyl]-4-carboxythiazolidine

試薬・触媒・溶媒 1

HCID 86737261Acetone sodium bicarbonate溶媒

実験手順

By means of the alkaline hydrolysis method of Example 54, the ethyl ester of Example 51 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 51 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

後処理

  1. customBy means of the alkaline hydrolysis method of Example 54
  2. customThis acid is also prepared

出典と根拠

ORDレコード
ord-3276e6d51ce04e0f984c16c2e5bea113
出典データセット
uspto-grants-1982_09
特許番号
US04348399

反応ノート

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