Hydrochloric Acid → HCID 20525070、化合物
反応式
[ClH:1].C(OC([NH:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]([N:16]1[CH:23]=[C:22]([F:24])[C:20](=[O:21])[NH:19][C:17]1=[O:18])=[O:15])=O)(C)(C)C>C(O)C>[ClH:1].[NH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]([N:16]1[CH:23]=[C:22]([F:24])[C:20](=[O:21])[NH:19][C:17]1=[O:18])=[O:15]参加物
4
実験手順
Hydrogen chloride gas was introduced to the solution of 1-[N-[3-(t-butoxycarbonylamino)propyl]carbamoyl]-5-fluorouracil (5.1 g.) which was prepared in Example 20 in ethanol (30 ml.) until precipitates were appeared for 1 hour with stirring under cooling with ice. The reaction mixture was further stirred for 1 hour at ambient temperature, and diethyl ether (100 ml.) was added therein. The resultant crystalline precipitates were collected by filtration and were dried over phosphoric anhydride to give 1-[N-(3-aminopropyl)carbamoyl]-5-fluorouracil hydrochloride (1.5 g.).