Benzene → 2,2,5-Trimethyl-3-(dichloroacetyl)-1,3-oxazolidine

HRID 1702917

反応式

HRID 1702917 の反応式
C1C=CC=CC=1.[CH3:7][C:8]1([CH3:14])[NH:12][CH2:11][CH:10]([CH3:13])[O:9]1.C(N(CC)CC)C.[Cl:22][CH:23]([Cl:27])[C:24](Cl)=[O:25]>O>[CH3:7][C:8]1([CH3:14])[N:12]([C:24](=[O:25])[CH:23]([Cl:27])[Cl:22])[CH2:11][CH:10]([CH3:13])[O:9]1

参加物

6

反応物 4

HCID 241Benzene2 回HCID 6593Dichloroacetyl chlorideHCID 8471TriethylamineHCID 95486Oxazolidine, 2,2,5-trimethyl-

生成物 1

HCID 620192,2,5-Trimethyl-3-(dichloroacetyl)-1,3-oxazolidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Eighteen milliliters (ml.) of a benzene solution containing 4.6 grams (g.) of 2,2,5-trimethyl oxazolidine was added to 25 ml. of benzene and 4.5 g. of triethylamine. Five and nine-tenths g. of dichloroacetyl chloride was added dropwise with stirring and cooling in an ice bath. When reaction was complete, the mixture was poured into water and the benzene layer separated, dried over anhydrous magnesium sulfate and the benzene removed under vacuum. Yield was 7.7 g. of an oil, nD30 =1.4950.

後処理

  1. additionwas added to 25 ml
  2. temperaturecooling in an ice bath
  3. customWhen reaction
  4. customthe benzene layer separated
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe benzene removed under vacuum

出典と根拠

ORDレコード
ord-46b33189bab2483b9e9674d84cb5b811
出典データセット
uspto-grants-1982_09
特許番号
US04350517

関連ノート

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