Hydrochloric Acid → 3-Oxo-3-(thiophen-3-yl)propanenitrile

HRID 1702968ノート

反応式

HRID 1702968 の反応式
N[C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)=[CH:3][C:4]#[N:5].Cl.C[OH:13]>>[O:13]=[C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[CH2:3][C:4]#[N:5]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54536012beta-Amino-3-thiopheneacrylonitrile

生成物 1

HCID 27400753-Oxo-3-(thiophen-3-yl)propanenitrile

実験手順

A 1.2 g. portion of β-amino-3-thiopheneacrylonitrile is added to 10 ml. of 1 N hydrochloric acid. A 40 ml. portion of methanol is added and the mixture is stirred for 3 hours. The mixture is evaporated in vacuo to a residue which is dissolved in 35 ml. of hot methanol and treated with charcoal. After cooling, petroleum ether is added, the mixture is filtered and the collected solid is discarded. The filtrate is evaporated and the residue is dissolved in 35 ml. of hot isopropanol and the insoluble material is filtered and discarded. The filtrate is cooled and the solid is collected giving the desired products as white plates, mp. 87°-88° C.

後処理

  1. customThe mixture is evaporated in vacuo to a residue which
  2. dissolutionis dissolved in 35 ml
  3. additionof hot methanol and treated with charcoal
  4. temperatureAfter cooling
  5. additionpetroleum ether is added
  6. filtrationthe mixture is filtered
  7. customThe filtrate is evaporated
  8. dissolutionthe residue is dissolved in 35 ml
  9. filtrationof hot isopropanol and the insoluble material is filtered
  10. temperatureThe filtrate is cooled
  11. customthe solid is collected

出典と根拠

ORDレコード
ord-af28c428355f491bb51822c43707b914
出典データセット
uspto-grants-1982_09
特許番号
US04350689

反応ノート

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