4(3H)-Quinazolinone, 3-amino-2-hydrazino- → 3-amino-2-(4-hydroxybutylamino)-quinazolin-4(3H)-one
反応式
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[NH:13]N>NCCCCO>[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[NH:13][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]参加物
3
実験手順
16 g of 3-amino-2-hydrazinoquinazolin-4(3H)-one were stirred in 48 ml of 4-aminobutanol at 160° C. for 3 days and the majority of the 4-aminobutanol was then distilled off under vacuum. The residue was diluted with water and the mixture was seeded and stored at 0° C. overnight to crystallize the product. The mixture was filtered and the recovered product was washed and dried to obtain 12.05 g of 3-amino-2-(4-hydroxybutylamino)-quinazolin-4(3H)-one.
後処理
- distillationthe majority of the 4-aminobutanol was then distilled off under vacuum
- additionThe residue was diluted with water
- customto crystallize the product
- filtrationThe mixture was filtered
- washthe recovered product was washed
- customdried
出典と根拠
- ORDレコード
- ord-07af5b9f35ab44a8b67e8e3dfb7b95c0
- 出典データセット
- uspto-grants-1982_09
- 特許番号
- US04350695
反応ノート
読み込み中…