HCID 20497519、化合物 → HCID 20524256、化合物

HRID 1702981ノート

反応式

HRID 1702981 の反応式
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[N:4]=[C:3]1[NH:14]N>NCCCCO>[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[N:4]=[C:3]1[NH:14][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]

参加物

3

反応物 1

HCID 20497519HCID 20497519、化合物

生成物 1

HCID 20524256HCID 20524256、化合物収率 126.7%

試薬・触媒・溶媒 1

HCID 258684-Amino-1-butanol溶媒

実験手順

20 g of 3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one were stirred in 100 ml of 4-aminobutanol at 175° C. for 24 hours and the majority of the 4-aminobutanol was then distilled off under vacuum. The residue was diluted with water to crystallize out the product and the mixture was filtered. The product was washed and dried to obtain 16.2 g of 3-amino-2-(4-hydroxybutylamino)-6-methylquinazolin-4(3H)-one.

後処理

  1. distillationthe majority of the 4-aminobutanol was then distilled off under vacuum
  2. additionThe residue was diluted with water
  3. customto crystallize out the product
  4. filtrationthe mixture was filtered
  5. washThe product was washed
  6. customdried

出典と根拠

ORDレコード
ord-e28a6e4f926c42078dcb238f07dd8c7b
出典データセット
uspto-grants-1982_09
特許番号
US04350695

反応ノート

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