Ammonium Acetate → N-(4-Hydroxyphenyl)glycine

HRID 1703061

反応式

HRID 1703061 の反応式
O.[OH:2][C:3]1[CH:13]=[CH:12][C:6](C(O)C([O-])=O)=[CH:5][CH:4]=1.[Na+].[C:15]([O-:18])(=[O:17])[CH3:16].[NH4+:19]>O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([NH:19][CH2:16][C:15]([OH:18])=[O:17])=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 517165Ammonium AcetateHCID 236981332-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrate

生成物 1

HCID 67149N-(4-Hydroxyphenyl)glycine収率 67%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
125 °C

実験手順

A mixture of sodium p-hydroxymandelate monohydrate (1.04 g.), ammonium acetate (2.0 g.) and water (0.5 ml.) is stirred and heated under reflux (internal temperature 125° C.) for 2.5 hours. Water (3 ml.) is added to the thick slurry thus obtained, the mixture is cooled and filtered and the solid residue is washed twice with water and then with acetone. There is thus obtained p-hydroxyphenylglycine (0.56 g., 66% yield).

後処理

  1. temperatureheated
  2. customthus obtained
  3. temperaturethe mixture is cooled
  4. filtrationfiltered
  5. washthe solid residue is washed twice with water

出典と根拠

ORDレコード
ord-5199c7298b8e4d23b317a13a977cf9e7
出典データセット
uspto-grants-1982_09
特許番号
US04350826

関連ノート

読み込み中…