Hydrochloric Acid → 4-[(8-Phenyloctyl)amino]benzoic acid

HRID 1703094ノート

反応式

HRID 1703094 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:26]=[CH:25][C:19]([C:20]([O:22]CC)=[O:21])=[CH:18][CH:17]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].C(O)C.O.Cl>O>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:22])=[O:21])=[CH:25][CH:26]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13079665Ethyl 4-[(8-phenyloctyl)amino]benzoateHCID 19096565Water ethanol

生成物 1

HCID 130796644-[(8-Phenyloctyl)amino]benzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 7 g. of ethyl p-[(8-phenyloctyl)amino]benzoate (prepared as described in Example 32), 7 g. of potassium hydroxide and 100 ml. of ethanol-water (9:1) is refluxed for 3.5 hours. The mixture is acidified while hot with concentrated hydrochloric acid, diluted with water, chilled and filtered. The solid is washed with water to give off-white crystals, m.p. 113°-115° C. Recrystallization from ethanol gives white crystals, m.p. 113°-115° C.

後処理

  1. additionA mixture of 7 g
  2. temperaturechilled
  3. filtrationfiltered
  4. washThe solid is washed with water
  5. customto give off-white crystals, m.p. 113°-115° C
  6. customRecrystallization from ethanol
  7. customgives white crystals, m.p. 113°-115° C.

出典と根拠

ORDレコード
ord-be82cff4703b4fa29ee1eeb72b517153
出典データセット
uspto-grants-1982_09
特許番号
US04350822

反応ノート

読み込み中…