化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 4-{[3-(4-Chlorophenyl)propyl]amino}benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Ethyl 4-{[3-(4-chlorophenyl)propyl]amino}benzoate | HCID 13079692 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-{[3-(4-Chlorophenyl)propyl]amino}benzoic acid | HCID 13079691 | — |
反応手順
A mixture of 16.3 g. of ethyl 4-[3-(p-chlorophenyl)propylamino]benzoate, 16.3 g. of potassium hydroxide and 200 ml. of 95% ethanol is refluxed for 3 hours. The mixture is diluted with 100 ml. of water and brought to pH 6 with concentrated hydrochloric acid. Chilling and filtering gave 15 g. of white crystals. Recrystallization from ethanol gave 8.6 g. of white crystals, m.p. 191°-192° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04350822 |
| 出典データセット | uspto-grants-1982_09 |
| ORD ID | ord-667c8f166a444fcd9c9bde9d6cb72efb |
| 出典メモ | uspto-grants-1982_09 |