Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate → 5-(4-Phenylbenzoyl)pyrrole-3-carboxylic Acid

HRID 1703290ノート

反応式

HRID 1703290 の反応式
[C:1]1([C:7]2[CH:24]=[CH:23][C:10]([C:11]([C:13]3[NH:17][CH:16]=[C:15]([C:18]([O:20]CC)=[O:19])[CH:14]=3)=[O:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:11]([C:13]3[NH:17][CH:16]=[C:15]([C:18]([OH:20])=[O:19])[CH:14]=3)=[O:12])=[CH:23][CH:24]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 12897070Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate

生成物 1

HCID 128970715-(4-Phenylbenzoyl)pyrrole-3-carboxylic Acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate (3.1 g.) was boiled in an open flask with 100 ml. of methanol and 70 ml. of 1 N sodium hydroxide for 1 hour by which time most of the methanol was removed by evaporation. The solution was cooled to room temperature, and product which had precipitated as the sodium salt recovered by filtration. The salt was stirred with 75 ml. of 1 N hydrochloric acid and 5-(4-phenylbenzoyl)pyrrole-3-carboxylic acid (1 g., m.p. >280° C.) recovered by filtration.

後処理

  1. customof 1 N sodium hydroxide for 1 hour by which time most of the methanol was removed by evaporation
  2. customproduct which had precipitated as the sodium salt
  3. filtrationrecovered by filtration
  4. filtrationof 1 N hydrochloric acid and 5-(4-phenylbenzoyl)pyrrole-3-carboxylic acid (1 g., m.p. >280° C.) recovered by filtration

出典と根拠

ORDレコード
ord-7ede9f5274a948478509f4650e674060
出典データセット
uspto-grants-1982_09
特許番号
US04351843

反応ノート

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