Acetic Acid → 2-Phenyl-1,2,4,5,6,7-hexahydro-indazol-3-one

HRID 1703436ノート

反応式

HRID 1703436 の反応式
[C:1]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C:6]1=O)([O:3]C)=O.[C:12]1([NH:18][NH2:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C1(C)C=CC=CC=1.C(O)(=O)C>O>[C:12]1([N:18]2[C:1](=[O:3])[C:5]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[NH:19]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 1140TolueneHCID 7516PhenylhydrazineHCID 170489Cyclohexanecarboxylic acid, 2-oxo-, methyl ester

生成物 1

HCID 31161752-Phenyl-1,2,4,5,6,7-hexahydro-indazol-3-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

32.9 Parts of a mixture containing 60% 2-carboethoxyclohexanone and 40% of 2-carbomethoxycyclohexanone purchased from Aldrich Chemical Company, Milwaukee, Wisconsin 53233, and 21.6 parts of phenylhydrazine purchased from Eastman Organic Chemicals Company, Rochester, N. Y. 14650, were admixed in 200 parts of toluene containing 2.0 parts of acetic acid. The mixture was refluxed for two hours with water removal. The resulting yellow suspension was cooled to 0°. The solid was collected, washed with hexane and dried. The yield was 37.1 parts of white solid with m.p. 178°-181°.

後処理

  1. addition32.9 Parts of a mixture containing 60% 2-carboethoxyclohexanone
  2. temperatureThe resulting yellow suspension was cooled to 0°
  3. customThe solid was collected
  4. washwashed with hexane
  5. customdried

出典と根拠

ORDレコード
ord-be914280c2b748fa9054d9dd8b7a7b22
出典データセット
uspto-grants-1978_11
特許番号
US04124373

反応ノート

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