4-Nitrophenol → Ethyl 2-(4-nitrophenoxy)tetradecanoate

HRID 1703449ノート

反応式

HRID 1703449 の反応式
[CH:1]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][CH:4]=[C:3]([OH:10])[CH:2]=1.[CH2:11]([O:13][C:14](=[O:29])[CH:15](Br)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:12]>CC(C)=O>[CH2:11]([O:13][C:14](=[O:29])[CH:15]([O:10][C:3]1[CH:4]=[CH:5][C:6]([N+:7]([O-:9])=[O:8])=[CH:1][CH:2]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:12]

参加物

4

反応物 2

HCID 9804-NitrophenolHCID 85791Tetradecanoic acid, 2-bromo-, ethyl ester

生成物 1

HCID 54095639Ethyl 2-(4-nitrophenoxy)tetradecanoate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

153 g (1.1 mol) of p-nitrophenol, 1.3 liters acetone and 336 g (1.0 mol) of ethyl-α-bromo-tetradecanoate were placed in a 5-liter 3-necked flask and heated on a steam bath with stirring, for 60 hours. The product was filtered to remove inorganic salt and then the acetone was distilled off under vacuo. The residual oil was taken up in hexane, filtered, and concentrated under vacuo. Yield of Intermediate I was 361 g. TLC Analysis (benzene) showed only one spot, indicating a single product.

後処理

  1. temperatureheated on a steam bath
  2. filtrationThe product was filtered
  3. customto remove inorganic salt
  4. distillationthe acetone was distilled off under vacuo
  5. filtrationfiltered
  6. concentrationconcentrated under vacuo

出典と根拠

ORDレコード
ord-a514fbd097f841368793f2eca21dad84
出典データセット
uspto-grants-1978_11
特許番号
US04124396

反応ノート

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