Dimethylformamide → 5-Cyanomethyl-2,7-dibromo-3-phenylbenzofuran

HRID 1703561

反応式

HRID 1703561 の反応式
Br[CH2:2][C:3]1[CH:4]=[C:5]([Br:19])[C:6]2[O:10][C:9]([Br:11])=[C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:7]=2[CH:18]=1.[CH3:20][N:21](C)C=O.[C-]#N.[Na+]>O>[C:20]([CH2:2][C:3]1[CH:4]=[C:5]([Br:19])[C:6]2[O:10][C:9]([Br:11])=[C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:7]=2[CH:18]=1)#[N:21]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 213199325-Bromomethyl-2,7-dibromo-3-phenylbenzofuran

生成物 1

HCID 213199065-Cyanomethyl-2,7-dibromo-3-phenylbenzofuran

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of 17.8 g. (0.040 mole) of 5-bromomethyl-2,7-dibromo-3-phenylbenzofuran in 150 ml. of N,N-dimethylformamide, 2.0 g. (0.04 mole) of sodium cyanide and 15 ml. of water is heated on a steam bath for 1.5 hours. The mixture is poured into one liter of water and stirred for about 16 hours. The mixture is extracted with 500 ml. of ethyl acetate, the extracts washed with water, then dried. Evaporation followed by trituration with hexane-ethyl acetate gives 5-cyanomethyl-2,7-dibromo-3-phenylbenzofuran as a white solid.

後処理

  1. extractionThe mixture is extracted with 500 ml
  2. washof ethyl acetate, the extracts washed with water
  3. customdried
  4. customEvaporation

出典と根拠

ORDレコード
ord-2e59e37a6eea4b8e8122b05895f28d40
出典データセット
uspto-grants-1978_11
特許番号
US04124704

関連ノート

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