Butylbenzene → 4-Butyl-2'-fluorobenzophenone

HRID 1703581

反応式

HRID 1703581 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[Cl-].[Al+3].[Cl-].[Cl-].[CH2:15]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:16][CH2:17][CH3:18]>C(=S)=S>[CH2:15]([C:19]1[CH:24]=[CH:23][C:22]([C:4]([C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[F:1])=[O:5])=[CH:21][CH:20]=1)[CH2:16][CH2:17][CH3:18]

参加物

5

反応物 3

HCID 7705ButylbenzeneHCID 98082-Fluorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 473524-Butyl-2'-fluorobenzophenone収率 62.5%

試薬・触媒・溶媒 1

HCID 6348Carbon Disulfide溶媒

実験手順

A 3.16 g (0.02 mole) of 2-fluoro benzoic acid chloride was dissolved in 30 ml of carbon disulfide and then, 4.0 g (0.03 mole) of anhydrous aluminum chloride was added to the solution. A 2.68 g (0.02 mole) of n-butyl benzene was further added to the mixture with stirring, and the reaction was carried out at room temperature for 18 hours. In accordance with the process of Example 1, the reaction mixture was treated to obtain 3.2 g of 4-n-butyl-2'-fluorobenzophenone having a boiling point of 180° to 190° C./5 mmHg. (yield of 62.5%).

後処理

  1. additionIn accordance with the process of Example 1, the reaction mixture was treated

出典と根拠

ORDレコード
ord-badff87eff144b81a28d22b3f4099785
出典データセット
uspto-grants-1978_11
特許番号
US04124726

関連ノート

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