Ethanol → 5-[(Ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester

反応式

[CH3:1][N:2]1[C:6]([NH2:7])=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:4]=[N:3]1.[CH:13]([OH:16])(O)O.[CH2:17](O)[CH3:18]>>[CH2:17]([O:16][CH:13]=[N:7][C:6]1[N:2]([CH3:1])[N:3]=[CH:4][C:5]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:18]

参加物

反応物 3

HCID 702Ethanol

HCID 271299Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate

HCID 5231666Orthoformic acid

生成物 1

HCID 867361415-[(Ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester収率 87%

実験手順

84.6 g. of 1-methyl-4-carboethoxy-5-aminopyrazole and 74.1 g. of orthoformic acid triethyul ester are heated together until the splitting off of ethanol has ended. The oily residue is distilled under oil pump vacuum to obtain 5-[(ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester b.p. 98°-102°; m.p. 32°-34° (yield87%).