Ammonia → Ribavirin
反応式
C[O:2][C:3]([C:5]1[N:9]=[CH:8][N:7]([C@@H:10]2[O:22][C@H:21]([CH2:23][O:24]C(=O)C)[C@@H:16]([O:17]C(=O)C)[C@H:11]2[O:12]C(=O)C)[N:6]=1)=O.[NH3:28]>CO>[C@@H:10]1([N:7]2[CH:8]=[N:9][C:5]([C:3]([NH2:28])=[O:2])=[N:6]2)[O:22][C@H:21]([CH2:23][OH:24])[C@@H:16]([OH:17])[C@H:11]1[OH:12]参加物
4
実験手順
A solution of 1-(2,3,5-tri-O-acetyl-β -D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (10.0 g., 26.0 mmole) in methanol (70 ml.) saturated at 0° with anhydrous ammonia was kept in a sealed pressure flask at 25° for 18 hrs. The product was crystallized from ethanol to give 1-(β -D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (5.70 g., 90.0%).
後処理
- customThe product was crystallized from ethanol
出典と根拠
- ORDレコード
- ord-df85ffb2cfb44b359c7b99493654d008
- 出典データセット
- uspto-grants-1978_11
- 特許番号
- USRE029835
反応ノート
読み込み中…