反応式
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:19])[CH2:13][S:12][C:11](=[N:14][CH:15]([CH3:17])[CH3:16])[N:10]2[CH3:18])=[CH:5][C:4]=1[S:20](=[O:23])(=[O:22])[NH2:21].C(=O)(O)[O-].[Na+]>O>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:19])[CH2:13][S:12][C:11](=[N:14][CH:15]([CH3:17])[CH3:16])[N:10]2[CH3:18])=[CH:5][C:4]=1[S:20](=[O:22])(=[O:23])[NH2:21]参加物
4
反応条件
- 温度
- 40 °C
実験手順
7 g of ground 4-(4-chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide were dissolved in 80 ml of 40° C. hot water and stirred for 30 minutes at 40° C. after adding it to a mixture of 60 ml of saturated sodium bicarbonate solution and 100 ml of water. After cooling to room temperature, the mixture was extracted with 200 ml of diethyl ether, the organic phase was dried over sodium sulfate and the solvent was distilled off under reduced pressure. The residue was dissolved in 40 ml of diisopropyl ether and the end product was precipitated by pouring it into 200 ml of stirred petroleum ether. Colorless solid body: decomposition beginning at 100° C., γC=N 1610 cm-1.
後処理
- additionafter adding it
- temperatureAfter cooling to room temperature
- extractionthe mixture was extracted with 200 ml of diethyl ether
- dry with materialthe organic phase was dried over sodium sulfate
- distillationthe solvent was distilled off under reduced pressure
- dissolutionThe residue was dissolved in 40 ml of diisopropyl ether
- customthe end product was precipitated
- additionby pouring it into 200 ml of stirred petroleum ether
- custombeginning at 100° C.
出典と根拠
- ORDレコード
- ord-b09903bc1023469f93d399d0b1e39950
- 出典データセット
- uspto-grants-1978_11
- 特許番号
- US04125614
関連ノート
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