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Bromo-4'-chloro-3'-sulfamoylacetophenone → 3-Ethyl-4-(4-chloro-3-sulfamoylphenyl)-2-isopropylimino-1,3-thiazolidine-4-ol-hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromo-4'-chloro-3'-sulfamoylacetophenone | HCID 12952390 | — |
| 反応物 | 1-Ethyl-3-isopropylthiourea | HCID 19650595 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 3-Ethyl-4-(4-chloro-3-sulfamoylphenyl)-2-isopropylimino-1,3-thiazolidine-4-ol-hydrochloride | HCID 22760539 | — |
反応手順
6.2 g of 2-bromo-4'-chloro-3'-sulfamoylacetophenone and 2.92 g of 1-ethyl-3-isopropylthiourea were heated in 40 ml of acetone for 15 minutes to 40° C., the mixture was stirred for another 30 minutes at room temperature and the crystals were filtered. Colorless crystalline solid body: melting point: 188° C. (decomposition).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04125614 |
| 出典データセット | uspto-grants-1978_11 |
| ORD ID | ord-584a2bac8be64985bd13627ad0065a54 |
| 出典メモ | uspto-grants-1978_11 |