Bromo-4'-chloro-3'-sulfamoylacetophenone → 4-(4-Chloro-3-sulfamoyl-phenyl)-2-cyclopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide
反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:19][C:20]([NH:22][CH3:23])=[S:21])[CH2:18][CH2:17]1>>[BrH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:21][C:20](=[N:19][CH:16]3[CH2:18][CH2:17]3)[N:22]2[CH3:23])=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]参加物
3
実験手順
4.15 g of 2-bromo-4'-chloro-3'-sulfamoylacetophenone were reacted with 1.95 g of 1-cyclopropyl-3-methylthiourea according to the prescription given in Example 23 and the oily precipitate was crystallized with diisopropyl ether. Colorless, crystalline solid body: melting point: 204° C. (decomposition).
後処理
- customthe oily precipitate was crystallized with diisopropyl ether
出典と根拠
- ORDレコード