N,N'-Dicyclopropylthiourea → 4-(4-Chloro-3-sulfamoylphenyl)-3-cyclopropyl-2-cyclopropylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 1703863ノート

反応式

HRID 1703863 の反応式
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:19][C:20]([NH:22][CH:23]2[CH2:25][CH2:24]2)=[S:21])[CH2:18][CH2:17]1>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:21][C:20](=[N:19][CH:16]3[CH2:18][CH2:17]3)[N:22]2[CH:23]2[CH2:25][CH2:24]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

参加物

3

反応物 2

HCID 17750075N,N'-DicyclopropylthioureaHCID 213167492,4'-Dichloro-3'-sulfamoylacetophenone

生成物 1

HCID 227605674-(4-Chloro-3-sulfamoylphenyl)-3-cyclopropyl-2-cyclopropylimino-1,3-thiazolidine-4-ol-hydrochloride

実験手順

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 3.1 g of 1,3-dicyclopropylthiourea were reacted according to the prescription given in Example 12 and the colorless crystalline precipitate of the end product was filtered off.

後処理

  1. filtrationthe colorless crystalline precipitate of the end product was filtered off

出典と根拠

ORDレコード
ord-7690362a8793417196e056a245d8ffa9
出典データセット
uspto-grants-1978_11
特許番号
US04125614

反応ノート

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