ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

1,3-Dipropyl-2-thiourea → 4-(4-Chloro-3-dimethylsulfamoylphenyl)-3-propyl-2-propylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 1703926
ノート
印刷プレビュー

反応式

HRID 1703926 の反応式
BrCC(C1C=CC([Cl:11])=C(S(=O)(=O)N(C)C)C=1)=O.C(NC(NCCC)=S)CC.Br.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2([OH:48])[CH2:40][S:39][C:38](=[N:41][CH2:42][CH2:43][CH3:44])[N:37]2[CH2:45][CH2:46][CH3:47])=[CH:32][C:31]=1[S:49](=[O:54])(=[O:53])[N:50]([CH3:52])[CH3:51]>C(OCC)C>[ClH:11].[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2([OH:48])[CH2:40][S:39][C:38](=[N:41][CH2:42][CH2:43][CH3:44])[N:37]2[CH2:45][CH2:46][CH3:47])=[CH:32][C:31]=1[S:49](=[O:54])(=[O:53])[N:50]([CH3:52])[CH3:51]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 28012141,3-Dipropyl-2-thioureaHCID 204768462-Bromo-4'-chloro-3'-dimethylsulfamoylacetophenoneHCID 227606734-(4-Chloro-3-dimethylsulfamoylphenyl)-3-propyl-2-propylimino-1,3-thiazolidine-4-ol-hydrobromide

生成物 1

HCID 227606754-(4-Chloro-3-dimethylsulfamoylphenyl)-3-propyl-2-propylimino-1,3-thiazolidine-4-ol-hydrochloride

試薬・触媒・溶媒 1

HCID 3283
Diethyl Ether
溶媒

実験手順

6.8 g of 2-bromo-4'-chloro-3'-dimethylsulfamoylacetophenone were reacted according to Example 23 with 3.3 g of 1,3-dipropylthiourea. After adding 200 ml of diethyl ether, 4-(4-chloro-3-dimethylsulfamoylphenyl)-3-propyl-2-propylimino-1,3-thiazolidine-4-ol-hydrobromide was separated as an oil. The solvent was decanted, the product was dissolved in 30 ml of water and extracted with 100 ml of ethyl acetate. After drying over sodium sulfate, the solvent was distilled off under reduced pressure, the amorphous residue was dissolved in 30 ml of ethanol and acidified with ethanolic hydrochloric acid. The solvent was distilled off, the residue was dissolved in 40 ml of water and the end product was obtained by lyophilization. Colorless amorphous solid body, decomposition beginning at 128° C., γ C=N 1615 cm-1.

後処理

  1. customwas separated as an oil
  2. customThe solvent was decanted
  3. dissolutionthe product was dissolved in 30 ml of water
  4. extractionextracted with 100 ml of ethyl acetate
  5. dry with materialAfter drying over sodium sulfate
  6. distillationthe solvent was distilled off under reduced pressure
  7. dissolutionthe amorphous residue was dissolved in 30 ml of ethanol
  8. distillationThe solvent was distilled off
  9. dissolutionthe residue was dissolved in 40 ml of water
  10. customthe end product was obtained by lyophilization
  11. customat 128° C.

出典と根拠

ORDレコード
ord-d7a20ada732648f2bcbd8bf7815b632b
出典データセット
uspto-grants-1978_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04125614

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート