2-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl- → HCID 3050036、化合物

HRID 1704731ノート

反応式

HRID 1704731 の反応式
[O:1]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([CH:16]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17]([CH3:19])=[O:18])[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[O:1]([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][N:13]([CH:16]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:17]([OH:18])[CH3:19])[CH2:14][CH2:15]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 30500342-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl-

生成物 1

HCID 3050036HCID 3050036、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

To 1-(N-2-phenoxy-ethyl-piperazino)-1-phenylacetone (1 mole) dissolved in anhydrous methanol (1 liter) is added BH4K (1 mole) portionwise, at 0° C., with stirring. On completion of the addition (1 hour), the reaction mixture is stirred 24 hours at room temperature. The methanol is removed in vacuo over a water-bath, the resulting material is then taken up into methylene chloride which is washed with water to neutral pH. Concentration gives white crystals which melt at 100° C.

後処理

  1. additionis added BH4K (1 mole) portionwise
  2. additionOn completion of the addition (1 hour)
  3. stirringthe reaction mixture is stirred 24 hours at room temperature
  4. customThe methanol is removed in vacuo over a water-bath
  5. washis washed with water to neutral pH
  6. concentrationConcentration
  7. customgives white crystals which
  8. custommelt at 100° C.

出典と根拠

ORDレコード
ord-268962db1cb4492fb5cf2efe65386f95
出典データセット
uspto-grants-1978_11
特許番号
US04127661

反応ノート

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