1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester → 8-Ethyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]-triazolo[1,5-a]pyrimidin-5(8H)-one

HRID 1704755

反応式

HRID 1704755 の反応式
[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:14]([O:16]CC)=O)[C:11]([NH:12][NH2:13])=[C:6]2[CH:5]=[N:4]1)[CH3:2].C(O[CH:22]=[N:23][C:24]#[N:25])C>O1CCOCC1>[CH2:1]([N:3]1[C:7]2[N:8]=[CH:9][C:10]3[C:14](=[O:16])[NH:25][C:24]4[N:12]([N:13]=[CH:22][N:23]=4)[C:11]=3[C:6]=2[CH:5]=[N:4]1)[CH3:2]

参加物

4

反応物 2

HCID 1623571-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl esterHCID 9920370Methanimidic acid, N-cyano-, ethyl ester

生成物 1

HCID 1355938528-Ethyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]-triazolo[1,5-a]pyrimidin-5(8H)-one

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

249 g. of 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]-pyridine-5-carboxylic acid, ethyl ester (1 mol.) are refluxed in 1.5 liters of dry dioxane together with 98 g. of ethoxymethylene cyanamide for 12 hours. After cooling to room temperature, the precipitated 8-ethyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]-pyrimidin-5(8H)-one is filtered off and recrystallized from dimethylformanide, yield 135 g. (53%); m.p. 355°-356°.

後処理

  1. filtrationthe precipitated 8-ethyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]-pyrimidin-5(8H)-one is filtered off
  2. customrecrystallized from dimethylformanide, yield 135 g

出典と根拠

ORDレコード
ord-c2f4d14374094373aec83390d6410216
出典データセット
uspto-grants-1978_11
特許番号
US04127655

関連ノート

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