Ammonia → 7-(2-Chloro-6-fluorobenzylamino)[1,2,5]thiadiazolo[3,4-d]pyrimidine

HRID 1704779

反応式

HRID 1704779 の反応式
[NH2:1][C:2]1[C:3]2[C:4](=[N:8][S:9][N:10]=2)[N:5]=[CH:6][N:7]=1.N.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:14]=1[CH2:15]Cl>>[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:14]=1[CH2:15][NH:1][C:2]1[C:3]2[C:4](=[N:8][S:9][N:10]=2)[N:5]=[CH:6][N:7]=1

参加物

4

反応物 3

HCID 222AmmoniaHCID 95769(1,2,5)Thiadiazolo(3,4-d)pyrimidin-7-amineHCID 1086751-Chloro-2-(chloromethyl)-3-fluorobenzene

生成物 1

HCID 204820257-(2-Chloro-6-fluorobenzylamino)[1,2,5]thiadiazolo[3,4-d]pyrimidine収率 25%

反応条件

温度
110 °C

実験手順

An autoclave was charged with 1.54 g. (0.01 mole) of 7-amino[1,2,5]thiadiazolo[3,4-d]pyrimidine prepared by the process set forth in Example 1, 5.1 g. (0.3 mole) ammonia and 4.48 g. (0.025 mole) 2-chloro-6-fluorobenzyl chloride. The vessel was sealed and the contents heated at 110° C. for 15 hours. After cooling and evaporation of the excess ammonia, the resulting solid was collected by filtration, washed successively with water and hexane to afford a 25% yield of product.

後処理

  1. additionAn autoclave was charged with 1.54 g
  2. customThe vessel was sealed
  3. temperatureAfter cooling
  4. customevaporation of the excess ammonia
  5. filtrationthe resulting solid was collected by filtration
  6. washwashed successively with water and hexane

出典と根拠

ORDレコード
ord-640dc70040b54c33ad486aca2e13e8f2
出典データセット
uspto-grants-1978_11
特許番号
US04127721

関連ノート

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