Diethylaminoethyl chloride → 4-[2-(diethylamino)ethyl]-2,8,10-trimethyl-4H-pyrazolo[1,5-a]-pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

反応式

[CH2:1]([N:3]([CH2:6][CH2:7]Cl)[CH2:4][CH3:5])[CH3:2].CN(CCCCl)C.[CH3:16][C:17]1[CH:35]=[C:20]2[NH:21][C:22](=[O:34])[C:23]3[CH:28]=[N:27][C:26]4[N:29]([CH3:33])[N:30]=[C:31]([CH3:32])[C:25]=4[C:24]=3[N:19]2[N:18]=1>>[CH2:1]([N:3]([CH2:4][CH3:5])[CH2:6][CH2:7][N:21]1[C:22](=[O:34])[C:23]2[CH:28]=[N:27][C:26]3[N:29]([CH3:33])[N:30]=[C:31]([CH3:32])[C:25]=3[C:24]=2[N:19]2[N:18]=[C:17]([CH3:16])[CH:35]=[C:20]12)[CH3:2]

参加物

反応物 3

HCID 13364Diethylaminoethyl chloride

HCID 669603-Chloro-N,N-dimethyl-1-propanamine

HCID 1357053792,8,10-trimethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido-[3,4-e]pyrimidin-5(8H)-one

生成物 1

HCID 227574744-[2-(diethylamino)ethyl]-2,8,10-trimethyl-4H-pyrazolo[1,5-a]-pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

実験手順

By substituting diethylaminoethyl chloride for the dimethylaminopropyl chloride and utilizing the 2,8,10-trimethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one product of Example 12 instead of 8-ethyl-2-methyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one in the procedure of Example 4, 4-[2-(diethylamino)ethyl]-2,8,10-trimethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one is obtained.