Triethyl phosphite → Diethyl 3-chloro-2-methylpropylphosphonate

HRID 1706170ノート

反応式

HRID 1706170 の反応式
Br[CH2:2][CH:3]([CH3:6])[CH2:4][Cl:5].[P:7]([O:14]CC)([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10]>>[Cl:5][CH2:4][CH:3]([CH3:6])[CH2:2][P:7](=[O:14])([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10]

参加物

3

反応物 2

HCID 31215Triethyl phosphiteHCID 955661-Bromo-3-chloro-2-methylpropane

生成物 1

HCID 20337215Diethyl 3-chloro-2-methylpropylphosphonate収率 57.2%

実験手順

A mixture of 1-bromo-3-chloro-2-methylpropane (95 g.) and triethyl phosphite (61.4 g.) was heated to reflux for 5.5 hours with stirring and then excess 1-bromo-3-chloro-2-methylpropane was distilled off under reduced pressure to give oily diethyl 3-chloro-2-methylpropylphosphonate (48.3 g.).

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 5.5 hours
  3. distillationexcess 1-bromo-3-chloro-2-methylpropane was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-c55080848a19478180f97cf3fdb8e005
出典データセット
uspto-grants-1980_06
特許番号
US04206156

反応ノート

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