化工社化工社 化学情報印刷レポート · 研究参考用
Formic Acid → Fosmidomycin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Magnesium Hydroxide | HCID 73981 | — |
| 反応物 | 3-(Hydroxyamino)propylphosphonic acid | HCID 342170 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Fosmidomycin | HCID 572 | 65.8% |
反応手順
An oily 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (12.05 g.), which was prepared by the reaction of 3-(N-hydroxyamino)propylphosphonic acid (15.5 g.), acetic anhydride (12.3 g.) and formic acid (9.8 ml.) conducted in substantially the same manner as that of Example (31), was dissolved in water (80 ml.) and treated with magnesium hydroxide (5.83 g.) for 15 minutes under ice-cooling with stirring.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04206156 |
| 出典データセット | uspto-grants-1980_06 |
| ORD ID | ord-d0d185827fa64e5797039853d4dfd715 |
| 出典メモ | uspto-grants-1980_06 |