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Dicyclohexylcarbodiimide → 5,6,6a,7,8,9,10,10a-Octahydro-2-(4-morpholinobutyryloxy)-10-hydroxymethyl-6,6-dimethyl-3-(1-methyl-4-phenylbutyl)benzo[c]quinoline Hydrochloride

HRID 1706258
ノート
印刷プレビュー

反応式

HRID 1706258 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH:12]([CH3:22])[CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[NH:8][C:7]([CH3:24])([CH3:23])[CH:6]1[CH2:25][CH2:26][CH2:27][CH:28]([CH2:29][OH:30])[CH:5]21.[ClH:31].[O:32]1[CH2:37][CH2:36][N:35]([CH2:38][CH2:39][CH2:40][C:41](O)=[O:42])[CH2:34][CH2:33]1.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[ClH:31].[O:32]1[CH2:37][CH2:36][N:35]([CH2:38][CH2:39][CH2:40][C:41]([O:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[CH:12]([CH3:22])[CH2:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[NH:8][C:7]([CH3:23])([CH3:24])[CH:6]2[CH2:25][CH2:26][CH2:27][CH:28]([CH2:29][OH:30])[CH:5]32)=[O:42])[CH2:34][CH2:33]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 127337464-Morpholin-4-Yl-Butyric Acid HydrochlorideHCID 203374355,6,6a,7,8,9,10,10a-Octahydro-2-hydroxy-10-hydroxymethyl-6,6-dimethyl-3-(1-methyl-4-phenylbutyl)benzo[c]quinoline

生成物 1

HCID 203374685,6,6a,7,8,9,10,10a-Octahydro-2-(4-morpholinobutyryloxy)-10-hydroxymethyl-6,6-dimethyl-3-(1-methyl-4-phenylbutyl)benzo[c]quinoline Hydrochloride

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒
2 回

実験手順

To a 25° C. solution of 5,6,6a,7,8,9,10,10a-octahydro-2-hydroxy-10-hydroxymethyl-6,6-dimethyl-3-(1-methyl-4-phenylbutyl)benzo[c]quinoline (626 mg., 1.5 mmole) in dry methylene chloride (25 ml.) is added 4-morpholinobutyric acid hydrochloride (0.315 g., 1.5 mmole) and the mixture stirred at room temperature under a nitrogen atmosphere. A 0.1 M solution of dicyclohexylcarbodiimide in methylene chloride (12.5 ml., 1.5 mmole) is added dropwise and the mixture stirred for 6 hours. It is then cooled in ice, filtered and evaporated to give the title product which is purified as the free base by column chromatography on silica gel.

後処理

  1. stirringthe mixture stirred for 6 hours
  2. temperatureIt is then cooled in ice
  3. filtrationfiltered
  4. customevaporated

出典と根拠

ORDレコード
ord-ef7c6c5344d84e4695af75ccaa423ec7
出典データセット
uspto-grants-1980_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04206225

反応ノート

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